Beasley B L, Davenport R W, Chase T N
Arch Neurol. 1977 Apr;34(4):255-6. doi: 10.1001/archneur.1977.00500160069016.
The oral administration of fenfluramine hydrochloride, which acts centrally to augment serotonin-mediated synaptic function, did not alter extrapyramidal signs in either untreated or levodopa-treated parkinsolian patients. These results support the contention that biochemical indices of serotonergic dysfunction in Parkinson disease do not reflect a critical role for serotonin-containing neural systems in the pathophysiology of parkinsonism and that serotonin-active drugs afford no significant therapeutic benefit to patients with this disorder.
口服盐酸芬氟拉明，其作用于中枢以增强5-羟色胺介导的突触功能，在未治疗的或左旋多巴治疗的帕金森病患者中均未改变锥体外系体征。这些结果支持以下观点：帕金森病中5-羟色胺能功能障碍的生化指标并不反映含5-羟色胺的神经系统在帕金森病病理生理学中的关键作用，并且5-羟色胺活性药物对患有这种疾病的患者没有显著的治疗益处。
