Munoz-Dorado J, Inouye S, Inouye M
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Rutgers, Piscataway 08854.
J Cell Biochem. 1993 Jan;51(1):29-33. doi: 10.1002/jcb.240510107.
Myxococcus xanthus, a gram-negative bacterium exhibits a spectacular life cycle and social behavior. Its developmental cycle and multicellular morphogenesis resemble those of eukaryotic slime molds such as Dictyostelium discoideum. On the basis of this resemblance, we explored the existence of eukaryotic-like protein serine/threonine kinases which are known to play important roles in signal transduction during development of D. discoideum. It was indeed found that M. xanthus contains a large family of protein serine/threonine kinases related to the eukaryotic enzymes. This is the first unambiguous demonstration of eukaryotic-like serine/threonine kinases in the prokaryotes.
黄色粘球菌是一种革兰氏阴性菌，具有独特的生命周期和社会行为。其发育周期和多细胞形态发生类似于真核黏菌，如盘基网柄菌。基于这种相似性，我们探索了真核样蛋白丝氨酸/苏氨酸激酶的存在，已知这些激酶在盘基网柄菌发育过程中的信号转导中起重要作用。确实发现黄色粘球菌含有一大类与真核酶相关的蛋白丝氨酸/苏氨酸激酶。这是原核生物中首次明确证明存在真核样丝氨酸/苏氨酸激酶。
