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The release of calcium from cardiac mitochondria: the importance of the calcium-protein ratio.

作者信息

Göring G G, Nayler W G, Spieckermann P G

出版信息

Basic Res Cardiol. 1977 Jan-Feb;72(1):77-81. doi: 10.1007/BF01906303.

DOI:10.1007/BF01906303
PMID:843324
Abstract

Using a DW 2 dual wavelength spectrophotometer (AMINCO) and murexide as a Ca2+ sensitive indicator it is shown that guinea-pig heart mitochondria can release accumulated Ca2+ without the influence of non-physiological material. The main factor which decides if accumulated Ca2+ is spontaneously released is the Ca2+/mitochondrial-protein ratio. Under appropriate assay conditions a critical intramitochondrial Ca2+ concentration is reached. Increasing this concentration leads to Ca2+-release.

摘要

相似文献

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引用本文的文献

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Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell.
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2
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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7
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8
Specific inhibition of mitochondrial Ca++ transport by ruthenium red.钌红对线粒体钙离子转运的特异性抑制作用。
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Aspects of energy-linked calcium accumulation by rat heart mitochondria.大鼠心脏线粒体与能量相关的钙积累方面
J Biol Chem. 1975 Oct 10;250(19):7863-70.
10
A protective effect of verapamil on hypoxic heart muscle.维拉帕米对缺氧心肌的保护作用。
Cardiovasc Res. 1976 Nov;10(6):650-62. doi: 10.1093/cvr/10.6.650.