Dahlén G H
Kliniskt kemiska laboratoriet, Norrlands Universitetssjukhus, Umeå.
Lakartidningen. 1993 Jan 27;90(4):259-62.
A highly significant association (p < 0.001) was found in 1971-1972 between pre-beta-1 lipoprotein and coronary heart disease. Later, pre-beta-1 lipoprotein was in fasting serum samples found to be equivalent to Lp(a) lipoprotein. Continuing structural and clinical studies further documented the high atherogenicity of Lp(a) and revealed probable pathogenetic mechanisms. Interest in Lp(a) has increased tremendously during the last few years due to the recent overwhelming support for an independent association between Lp(a) and atherosclerotic disorders and the revelations of its fascinating structure. The structure of Lp(a), its association with clinical disorders and probable pathogenetic mechanisms are exemplified and discussed in relation to type of developed atheromas, their susceptibility to disruption and the importance of inherited high Lp(a) levels for the thrombotic complications.
1971年至1972年期间，发现前β-1脂蛋白与冠心病之间存在高度显著的关联（p < 0.001）。后来，在空腹血清样本中发现前β-1脂蛋白等同于Lp(a)脂蛋白。持续的结构和临床研究进一步证明了Lp(a)的高致动脉粥样硬化性，并揭示了可能的发病机制。在过去几年中，由于最近对Lp(a)与动脉粥样硬化性疾病之间独立关联的压倒性支持以及其迷人结构的揭示，人们对Lp(a)的兴趣急剧增加。结合所形成的动脉粥样硬化斑块的类型、它们对破裂的易感性以及遗传性高Lp(a)水平对血栓形成并发症的重要性，举例说明了Lp(a)的结构、其与临床疾病的关联以及可能的发病机制并进行了讨论。
