Cioffi G A, Robin A L, Eastman R D, Perell H F, Sarfarazi F A, Kelman S E
Glaucoma Service, University of Maryland, Baltimore.
Ophthalmology. 1993 Jan;100(1):57-62.
Glaucoma is an optic neuropathy in which changes in the appearance of both the optic nerve head and the surrounding tissues are important in both diagnosing its presence and progression. Accurate methods to objectively document the appearance of the optic nerve are necessary. The confocal laser scanning ophthalmoscope (Zeiss) is a new prototype instrument that may have the capability to accurately perform this function.
The authors performed a prospective pilot study evaluating the ability of the confocal laser scanning ophthalmoscope to reproduce three-dimensional optic nerve images. Each retinal image contained 600,000 bytes of information. Thirty discrete images of the right optic nerves of 19 visually normal volunteers were obtained. Depth measurements were compared from the same 100 x 100 micron areas (neighborhoods).
Image comparisons found the variability of depth measurements for the entire image were within 102 microns (95% confidence interval). Sixty percent of the depth measurements were reproducible within 100 microns. Variability of the depth measurements was greatest where the neuroretinal rim sloped at the edge of the optic cup and lowest in the peripapillary area.
The confocal laser scanning ophthalmoscope has the potential to be a safe, rapid, and reproducible method of imaging ocular structures.
青光眼是一种视神经病变，其中视神经乳头及其周围组织外观的变化对于诊断其存在和进展都很重要。因此，需要准确的方法来客观记录视神经的外观。共焦激光扫描检眼镜（蔡司）是一种新型的原型仪器，可能有能力准确执行这一功能。
作者进行了一项前瞻性初步研究，评估共焦激光扫描检眼镜再现三维视神经图像的能力。每张视网膜图像包含600,000字节的信息。获取了19名视力正常志愿者右眼视神经的30张离散图像。对同一100×100微米区域（邻域）的深度测量值进行比较。
图像比较发现，整个图像深度测量值的变异性在102微米以内（95%置信区间）。60%的深度测量值在100微米内可重复。在视杯边缘神经视网膜边缘倾斜处，深度测量值的变异性最大，而在视乳头周围区域最小。
共焦激光扫描检眼镜有可能成为一种安全、快速且可重复的眼部结构成像方法。
