Shakib F, Pritchard D I, Walsh E A, Smith S J, Powell-Richards A, Kumar S, Edmonds P
Department of Immunology, University of Nottingham, UK.
Parasite Immunol. 1993 Jan;15(1):47-53. doi: 10.1111/j.1365-3024.1993.tb00571.x.
In this study we have demonstrated significantly elevated levels of circulating IgG autoanti-IgE antibody in hookworm infected individuals from Kebasob village on Karkar Island, Papua New Guinea. Although anti-IgE activity was demonstrable in IgG1, IgG3 and IgG4, IgG1 was by far the most important subclass of IgG anti-IgE in terms of frequency of detection (34/39; 87.2%) and magnitude of increase (P = 0.0000); with IgG3 (16/39; 41.0%) and IgG4 (15/39; 38.5%) antibodies being considerably less prevalent. Plasma levels of IgG1 anti-IgE (P = 0.0019) and IgG3 anti-IgE (P = 0.0034) showed significant correlations with total IgE concentrations, but not with IgE specific to excretory-secretory worm products; thus suggesting that anti-IgE synthesis is more related to polyclonal hyper IgE production than to antigen-specific IgE stimulation. No correlation was seen between IgG subclass anti-IgE levels and faecal egg counts or worm burden. Given that our data failed to show a negative or a positive correlation between anti-IgE and the degree of infection with hookworm, it is tempting to speculate that the main role of autoanti-IgE is to provide the host with protection against immune complex- and IgE-mediated hypersensitivity reactions to parasitic antigens.
在本研究中，我们已证实在巴布亚新几内亚卡尔卡尔岛凯巴索布村感染钩虫的个体中，循环IgG自身抗IgE抗体水平显著升高。尽管在IgG1、IgG3和IgG4中均可检测到抗IgE活性，但就检测频率（34/39；87.2%）和升高幅度（P = 0.0000）而言，IgG1是IgG抗IgE中迄今为止最重要的亚类；而IgG3（16/39；41.0%）和IgG4（15/39；38.5%）抗体的普遍性则低得多。IgG1抗IgE（P = 0.0019）和IgG3抗IgE（P = 0.0034）的血浆水平与总IgE浓度呈显著相关，但与排泄分泌性蠕虫产物特异性IgE无关；因此表明抗IgE合成与多克隆高IgE产生的关系比与抗原特异性IgE刺激的关系更大。未观察到IgG亚类抗IgE水平与粪便虫卵计数或蠕虫负荷之间存在相关性。鉴于我们的数据未能显示抗IgE与钩虫感染程度之间存在负相关或正相关，不禁推测自身抗IgE的主要作用是为宿主提供保护，使其免受针对寄生虫抗原的免疫复合物和IgE介导的超敏反应。
