Kamran S, Usmani S S, Wapnir R A, Mehta R, Harper R G
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Pediatr Res. 1993 Jan;33(1):32-5. doi: 10.1203/00006450-199301000-00007.
Random motility and chemotaxis of polymorphonuclear leukocytes (PMN) was evaluated after in vitro exposure to 0, 300, 600, and 900 ng/mL (0.84, 1.68, and 2.52 mumol/L) of indomethacin. PMN were obtained from cord blood of 22 preterm infants of less than 37 wk gestation. For comparison, PMN were obtained from cord blood of seven healthy full-term infants and from venous blood of 10 normal adults. In preterm infants, a significant decrease of random motility and chemotaxis of PMN was noted at all three drug concentrations; impairment of PMN function was dose dependent in the three groups (p < 0.0001), with the greatest effect seen at 900 ng/mL (2.52 mumol/L). Significant impairment of random motility was noted in full-term infants when compared with adults at all indomethacin concentrations and in chemotaxis at 300 and 600 ng/mL (0.84 and 1.68 mumol/L). The study indicates that indomethacin has an adverse effect on PMN random motility and chemotaxis, which is more pronounced in preterm infants.
在体外将多形核白细胞（PMN）暴露于0、300、600和900 ng/mL（0.84、1.68和2.52 μmol/L）的吲哚美辛后，评估其随机运动性和趋化性。PMN取自22名孕周小于37周的早产婴儿的脐带血。作为对照，PMN取自7名健康足月婴儿的脐带血以及10名正常成年人的静脉血。在早产婴儿中，在所有三种药物浓度下均观察到PMN的随机运动性和趋化性显著降低；三组中PMN功能的损害呈剂量依赖性（p < 0.0001），在900 ng/mL（2.52 μmol/L）时作用最为明显。与成年人相比，在所有吲哚美辛浓度下，足月婴儿的随机运动性均有显著损害，在300和600 ng/mL（0.84和1.68 μmol/L）时趋化性也有显著损害。该研究表明，吲哚美辛对PMN的随机运动性和趋化性有不良影响，在早产婴儿中更为明显。
