Bernardis L L, Ciesla A, Bellinger L L
Neurovisceral Laboratory, Department of Veterans Affairs Medical Center, Buffalo, NY 14215.
Physiol Behav. 1993 Jan;53(1):59-64. doi: 10.1016/0031-9384(93)90011-4.
Weanling and mature rats with dorsomedial hypothalamic nucleus lesions (DMNL rats) show reduced ponderal and linear growth and hypophagia and hypodipsia in the presence of normal body composition and anabolic hormone levels. The present study was conducted to assess their reproductive/parenting capacity and some offspring parameters. Four groups were used: DMNL mothers and fathers, DMNL mothers and control (SCON) fathers, SCON mothers and DMNL fathers, and SCON mothers and SCON fathers. The constituent rats of each group were bred to yield between 14 and 22 litters. The smallest litter size, litter weight, mean pup weight, percent of live-born and percent of weaned pups and greatest percentage of still-born pups were recorded when both parents were DMNL rats. The latter parents also cannibalized the majority of litters. The above parameters improved when only one parent was a DMNL rat, but this was still significantly below the offspring of SCON x SCON parents. The DMN is not part of the classical hypophysiotropic area (HTA), but earlier findings indicate hyperprolactinemia in DMNL rats. Therefore, the lesion-induced hypophagia during gestation and the postpartum neuroendocrine profile of the DMNL mothers may be the cause of the observed litter deficiencies and poor survival.
患有下丘脑背内侧核损伤的断乳和成年大鼠（DMNL大鼠），在身体成分和合成代谢激素水平正常的情况下，体重和体长增长减缓，摄食和饮水减少。本研究旨在评估它们的生殖/育儿能力以及一些后代参数。实验使用了四组大鼠：DMNL雄鼠和雌鼠、DMNL雌鼠和对照（SCON）雄鼠、SCON雌鼠和DMNL雄鼠、SCON雌鼠和SCON雄鼠。每组的大鼠进行繁殖，产仔14至22窝。当双亲均为DMNL大鼠时，记录到最小的窝仔数、窝仔体重、平均幼崽体重、活产幼崽百分比、断奶幼崽百分比以及最高的死产幼崽百分比。后一组的双亲还会吃掉大部分窝仔。当只有一方是DMNL大鼠时，上述参数有所改善，但仍显著低于SCON×SCON双亲的后代。DMN并非经典促垂体区（HTA）的一部分，但早期研究结果表明DMNL大鼠存在高催乳素血症。因此，妊娠期损伤诱导的摄食减少以及DMNL雌鼠产后的神经内分泌特征可能是观察到的窝仔缺陷和低存活率的原因。
