抗体特异性的遗传决定因素。基因易位与融合，抗体产生细胞分化的分子基础。

Genetic determination of antibody specificity. Gene translocation and fusion, the molecular basis for the differentiation of the antibody-producing cell.

作者信息

Hilschmann N, Barnikol H U, Kratzin H, Altevogt P, Engelhard M, Barnikol-Watanabe S

出版信息

Naturwissenschaften. 1978 Dec;65(12):616-39. doi: 10.1007/BF00401905.

DOI:10.1007/BF00401905

Abstract

The best system for the study of cell differentiation is a cell which in its differentiated state differs only by one product. This is the case in the immune system. The undifferentiated, but omnipotent stem cell differentiates into a committed B cell which produces only one type of specific antibody out of a million different, genetically fixed possibilities. Gene translocation and fusion is the basis of this differentiation process.

摘要

研究细胞分化的最佳系统是一种在分化状态下仅因一种产物而不同的细胞。免疫系统就是这种情况。未分化但全能的干细胞分化为定向B细胞，在百万种不同的、基因固定的可能性中，该B细胞仅产生一种特定抗体。基因易位和融合是这一分化过程的基础。