Shabaik A S, Cox C E, Clark R A, Reintgen D S, Humphrey E J, Nicosia S V
Department of Pathology, University of South Florida Health Sciences Center, Tampa.
Acta Cytol. 1993 Jan-Feb;37(1):10-5.
Intraoperative evaluation of nonpalpable breast lesions by frozen section frequently is not performed because of potential tissue loss, sampling errors and frozen section artifacts. In a retrospective review we found that only 50 of 503 needle-localized breast biopsies (NLBBs) were evaluated at our institution by frozen section (FS), with a sensitivity of 88%. However, intraoperative evaluation of such lesions may be essential to single-stage and cost-effective management. To this end, this study evaluated the diagnostic accuracy and potential clinical role of intraoperative imprint cytology (IIC) in NLBB. A total of 88 lesions were evaluated by IIC and permanent histology. Fifteen of them were also concomitantly evaluated by FS. All but one deferred cytologic diagnoses were correct. Twelve of 15 FS diagnoses were correct, 2 were deferred, and 1 was false negative. The data suggest that IIC may circumvent some of the difficulties associated with FS, thereby allowing immediate clinical management and later definitive histologic typing and evaluation of prognostic parameters in nonpalpable breast lesions.
由于存在潜在的组织损失、采样误差和冰冻切片假象，术中通过冰冻切片对不可触及的乳腺病变进行评估的情况并不常见。在一项回顾性研究中，我们发现，在我们机构中，503例针吸定位乳腺活检（NLBB）中只有50例通过冰冻切片（FS）进行了评估，敏感性为88%。然而，对此类病变进行术中评估对于单阶段和具有成本效益的管理可能至关重要。为此，本研究评估了术中印片细胞学检查（IIC）在NLBB中的诊断准确性和潜在临床作用。共有88个病变通过IIC和永久组织学进行了评估。其中15个病变还同时通过FS进行了评估。除1例假阴性外，所有延迟的细胞学诊断均正确。15例FS诊断中有12例正确，2例延迟，1例假阴性。数据表明，IIC可能规避了一些与FS相关的困难，从而能够立即进行临床管理，并在之后对不可触及的乳腺病变进行明确的组织学分型和预后参数评估。
