大鼠静脉注射铅后的潴留、分布及排泄
Retention, distribution, and excretion of lead by the rat after intravenous injection.
作者信息
Morgan A, Holmes A, Evans J C
出版信息
Br J Ind Med. 1977 Feb;34(1):37-42. doi: 10.1136/oem.34.1.37.
The distribution and excretion of lead was studied during a period of about a week after a single intravenous injection of 203Pb as chloride accompanied by less than 1 microng of lead carrier. The peak concentration in venous blood was reached after about an hour when it contained 35 to 40% of the administered activity. The subsequent decline in concentration was much more rapid than is observed in man. The main storage organs were the kidneys and bone. Initially, 20% of the dose could be accounted for in the kidney and the biological half-life was about 100 hours. The level in bone built up rapidly at first and then more slowly. After a week, between 25 and 30% of the dose was present in bone.
在单次静脉注射203Pb氯化物（伴有少于1微克铅载体）后的大约一周时间内，对铅的分布和排泄进行了研究。静脉血中的峰值浓度在约一小时后达到，此时其含有给药活性的35%至40%。随后浓度的下降比在人类中观察到的要快得多。主要的储存器官是肾脏和骨骼。最初，剂量的20%可在肾脏中找到，生物半衰期约为100小时。骨骼中的水平起初迅速上升，然后上升得较慢。一周后，剂量的25%至30%存在于骨骼中。
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