Lin C N, Shieh W L, Ko F N, Teng C M
Natural Products Research Center, Kaohsiung Medical College, Taiwan, R.O.C.
Biochem Pharmacol. 1993 Jan 26;45(2):509-12.
Eight naturally occurring prenylflavonoids were tested for their antiplatelet activities in rabbit platelet suspension. Cyclomorusin and artomunoxanthone showed strong inhibition of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation. Cyclomulberrin, dihydroisocycloartomunin, cyclocommunol and cyclocommunin showed strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation. Cyclomorusin also inhibited markedly collagen-induced platelet aggregation. Cyclocommunin, dihydroisocycloartomunin and cyclomulberrin also showed slight but significant antiplatelet effects on the aggregation induced by PAF. Of the compounds tested, cyclocommunin exhibited the most potent inhibition of platelet aggregation induced by collagen (IC50 = 14.4 microM) and AA (IC50 = 12.5 microM). Thromboxane B2 formation caused by AA was suppressed by cyclocommunin and artomunoxanthone.
在兔血小板悬液中测试了八种天然存在的异戊烯基黄酮的抗血小板活性。环桑皮素和蒿甲醚黄烷酮对血小板活化因子（PAF；1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）诱导的血小板聚集有强烈抑制作用。环桑皮苷、二氢异环蒿甲醚、环桑皮醇和环桑皮素对花生四烯酸（AA）和胶原诱导的血小板聚集有强烈抑制作用。环桑皮素对胶原诱导的血小板聚集也有明显抑制作用。环桑皮素、二氢异环蒿甲醚和环桑皮苷对PAF诱导的聚集也有轻微但显著的抗血小板作用。在所测试的化合物中，环桑皮素对胶原（IC50 = 14.4 microM）和AA（IC50 = 12.5 microM）诱导的血小板聚集表现出最有效的抑制作用。环桑皮素和蒿甲醚黄烷酮抑制了由AA引起的血栓素B2的形成。
