Sickle-cell disease, hemophilia, and hematology.

Primary hematologic disorders and the hematologic problems associated with systemic rheumatologic disease have widespread and significant implications for the clinical management of rheumatic disease. This article reviews recently published information on the epidemiology, pathophysiology, and management of hemoglobinopathies, hemophilia, and other hematologic pathologies associated with significant rheumatologic manifestations.