Condamine L, Hermine O, Alvin P, Levine M, Rey C, Courtecuisse V
Département de Pédiatrie, Centre Hospitalo-Universitaire de Bicêtre, France.
Br J Haematol. 1993 Jan;83(1):166-8. doi: 10.1111/j.1365-2141.1993.tb04648.x.
We report one case of acquired sideroblastic anaemia in a patient treated for Wilson's disease with triethylene tetramine dihydrochloride (TTH). No other cause of acquired sideroblastic anaemia was found, and neither iron nor pyridoxine therapy could correct this anaemia. In contrast, decreasing the dose of TTH led to disappearance of ringed sideroblasts. Thus TTH should be added as a further cause of secondary acquired sideroblastic anaemia. The pathophysiology of this finding, probably linked to an abnormality of mitochondrial iron metabolism, is briefly discussed.
我们报告一例在用二盐酸三乙烯四胺（TTH）治疗威尔逊病的患者中发生的获得性铁粒幼细胞贫血。未发现获得性铁粒幼细胞贫血的其他病因，铁剂和维生素B6治疗均无法纠正该贫血。相反，降低TTH剂量导致环形铁粒幼细胞消失。因此，TTH应被列为继发性获得性铁粒幼细胞贫血的又一病因。本文简要讨论了这一发现的病理生理学，其可能与线粒体铁代谢异常有关。
