Niedźwiedzki T, Dabrowski Z, Miszta H, Pawlikowski M
Surgery Department No. III, Medical Academy, Cracow, Poland.
Biomaterials. 1993;14(2):115-21. doi: 10.1016/0142-9612(93)90221-m.
In experimental studies on rabbits, osteogenic properties of stromal cells were confirmed after in vitro growth for 7 and 14 d. The cell suspension was percutaneously transplanted into a surgically produced bone defect in the rabbit's radius. The bone scar produced was X-rayed, and histologically and mineralogically examined after 10, 20 and 40 d follow-ups. Differences in the bone defect healing process (the healing rate and the type of bone tissue produced) were shown between the experimental and the control foreleg. Within the experimental foreleg, healing was considerably accelerated with compact bone formation on a membranous matrix, whilst in the control foreleg, a coarse, fibrous woven bone on a cartilaginous matrix was dominant.
在对兔子的实验研究中，基质细胞在体外培养7天和14天后的成骨特性得到了证实。将细胞悬液经皮移植到兔子桡骨手术造成的骨缺损处。对产生的骨瘢痕进行X射线检查，并在随访10天、20天和40天后进行组织学和矿物学检查。实验前肢和对照前肢在骨缺损愈合过程（愈合率和产生的骨组织类型）上显示出差异。在实验前肢中，愈合明显加速，在膜性基质上形成致密骨，而在对照前肢中，软骨基质上的粗大纤维编织骨占主导。
