McCann S R, Lawler M
Department of Haematology and Genetics, St James Hospital, Dublin, Ireland.
Bone Marrow Transplant. 1993 Feb;11(2):91-4.
Residual recipient haematopoietic cells may coexist with donor haemopoietic tissue following BMT. This is known as mixed chimaerism. The incidence of mixed chimaerism varies with the sensitivity of the detection system used; DNA based methodologies are the most sensitive. The influence of mixed chimaerism on leukaemia relapse and graft rejection is unclear. The lineages in which mixed chimaerism occurs may affect outcome.
骨髓移植后，受者残留的造血细胞可能与供者造血组织共存。这被称为混合嵌合体。混合嵌合体的发生率因所用检测系统的敏感性而异；基于DNA的方法最为敏感。混合嵌合体对白血病复发和移植物排斥的影响尚不清楚。发生混合嵌合体的谱系可能会影响结果。
