Korkmaz S, Carlsson S, Wahlström G
Department of Pharmacology, University of Umeå, Sweden.
Brain Res. 1993 Jan 15;600(2):345-8. doi: 10.1016/0006-8993(93)91395-9.
Male rats at six different ages received diazepam on a 4-day treatment schedule. Cross-tolerance to hexobarbital was tested several times during withdrawal period with an anaesthesia threshold technique. Pattern of cross-tolerance was different at different ages. Thus, age and maturation of the rat is a variable which must be considered in studies of tolerance to diazepam.
六个不同年龄的雄性大鼠按4天治疗方案接受地西泮治疗。在撤药期，采用麻醉阈值技术多次测试对己巴比妥的交叉耐受性。不同年龄的交叉耐受性模式不同。因此，大鼠的年龄和成熟度是在研究地西泮耐受性时必须考虑的一个变量。
