Reeve V E, Bosnic M, Rozinova E
Department of Veterinary Pathology, University of Sydney, Australia.
Immunology. 1993 Jan;78(1):99-104.
Carnosine is a naturally occurring histidine-containing dipeptide in mammalian tissues for which a physiological role has not been defined. It has antioxidant properties, but has also been shown to be related metabolically to histidine and histamine, and to have immunopotentiating properties in vivo. It is shown here that carnosine presented topically or in the diet, potentiated the contact hypersensitivity reaction in hairless mice. Carnosine also prevented the systemic suppression of this reaction following exposure of the dorsal skin to ultraviolet B (UVB) radiation. Furthermore, carnosine prevented the systemic suppression caused by a topically applied lotion containing cis urocanic acid, indicating that it may act in competition with this UVB photoproduct which is believed to initiate many of the suppressive effects of UVB radiation.
肌肽是哺乳动物组织中天然存在的含组氨酸二肽，其生理作用尚未明确。它具有抗氧化特性，但也已表明在代谢上与组氨酸和组胺相关，并且在体内具有免疫增强特性。本文表明，局部应用或通过饮食摄入肌肽可增强无毛小鼠的接触性超敏反应。肌肽还可预防背部皮肤暴露于紫外线B（UVB）辐射后该反应的全身抑制。此外，肌肽可预防含顺式尿刊酸的局部应用洗剂引起的全身抑制，这表明它可能与这种UVB光产物竞争发挥作用，据信该光产物引发了UVB辐射的许多抑制作用。
