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与高脂血症家族史相关的穆尔-托雷综合征。

Muir-Torre syndrome associated with a family history of hyperlipidemia.

作者信息

Ródenas J M, Herranz M T, Tercedor J, López B, Naranjo R, Delgado V

机构信息

Department of Dermatology, Hospital Universitario, Granada, Spain.

出版信息

J Am Acad Dermatol. 1993 Feb;28(2 Pt 2):285-8. doi: 10.1016/0190-9622(93)70035-r.

Abstract

The Muir-Torre syndrome is a rare disorder characterized by sebaceous neoplasms of the skin and multiple visceral malignancies. The syndrome appears to be a familial, autosomal dominant condition. We diagnosed this syndrome in a previously unreported patient and found a personal and family history of malignancies and hyperlipidemia. The association of Muir-Torre syndrome with a family history of hyperlipidemia, another autosomal dominant condition, has not been previously reported. The possible genetic relationship between the two disorders is discussed.

摘要

穆尔-托雷综合征是一种罕见的疾病,其特征为皮肤皮脂腺肿瘤和多种内脏恶性肿瘤。该综合征似乎是一种家族性常染色体显性遗传病。我们在一名此前未报告过的患者中诊断出了这种综合征,并发现其有个人及家族恶性肿瘤病史和高脂血症病史。穆尔-托雷综合征与高脂血症家族史(另一种常染色体显性遗传病)之间的关联此前尚未见报道。本文讨论了这两种疾病之间可能的遗传关系。

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