Fujita M, Miyachi Y, Furukawa F, Toichi E, Furukawa I, Nakajima N, Imamura S
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
J Am Acad Dermatol. 1993 Feb;28(2 Pt 2):355-60. doi: 10.1016/0190-9622(93)70054-w.
Cutaneous T-cell lymphoma expressing gamma delta T-cell receptors (TCRs) is rare; only a few cases have been reported. We report another case of the disease that had a fatal outcome and differs from two previously reported cases in its clinical, histologic, and immunohistochemical aspects. The patient had multiple skin tumors with central crusts; she showed no response to chemotherapy and died within 1 year. Histologic findings included perivascular infiltrates in the dermis and subcutaneous tissue with no epidermotropism; the large lymphoid cells had a phenotype of CD1-, CD3+, CD4-, CD8-, CD25-/+, CD30-, CD38-/+, HLA-DR+, and gamma delta TCR (beta F1-, TCR delta 1+, delta TCS1-, Ti gamma A+, BB3-). The differences in the phenotype of gamma delta T-cell malignancies may reflect the uniqueness of its clinical and histologic features. A study of gamma delta T-cell malignancies may disclose important biologic features of gamma delta TCR+ cells.
表达γδ T细胞受体（TCR）的皮肤T细胞淋巴瘤很罕见；仅有少数病例被报道。我们报告了该疾病的另一例病例，其预后不良，在临床、组织学和免疫组化方面与之前报道的两例病例不同。该患者有多个伴有中央结痂的皮肤肿瘤；她对化疗无反应，在1年内死亡。组织学表现包括真皮和皮下组织的血管周围浸润，无亲表皮现象；大淋巴细胞的表型为CD1 -、CD3 +、CD4 -、CD8 -、CD25 -/+、CD30 -、CD38 -/+、HLA - DR +和γδ TCR（βF1 -、TCRδ1 +、δTCS1 -、TiγA +、BB3 -）。γδ T细胞恶性肿瘤表型的差异可能反映其临床和组织学特征的独特性。对γδ T细胞恶性肿瘤的研究可能会揭示γδ TCR +细胞的重要生物学特征。
