Kanamori Y
Department of Obstetrics and Gynecology, Tottori University, Faculty of Medicine, Yonago.
Nihon Sanka Fujinka Gakkai Zasshi. 1993 Jan;45(1):31-7.
The purpose of this study was to evaluate the usefulness of internal iliac artery infusion chemotherapy with cisplatin (CDDP) for uterine cancer. The rabbit model for internal iliac artery infusion was designed and then induced. The rabbits (average BW 3.5kg) were treated with CDDP (1.7mg/kg) via either the internal iliac artery (IA) or peripheral vein (IV) as the control. The rabbits were infused with CDDP via the IA for 2 minutes, 20 minutes or 2 hours, or via IV for 2 minutes or 20 minutes. Platinum (Pt) concentrations were measured in the serum and tissues of the uterus and kidney after CDDP infusion. Concentrations of filtrated Pt in serum were significantly lower and concentrations of Pt in uterine tissue were significantly higher after IA infusion. The highest concentration of Pt in uterine tissue was obtained after 20 minutes of IA infusion. However, the uterine Pt concentration after IA infusion for 2 hours did not differ from that after IV infusion. A significant amount of Pt was also retained in kidney tissue after IA infusion, which was not different from that after IV infusion. These findings with the rabbit model suggest that IA infusion of CDDP for 20 minutes is useful in treating uterine cancer.
本研究的目的是评估顺铂（CDDP）髂内动脉灌注化疗对子宫癌的有效性。设计并建立了髂内动脉灌注的兔模型。将平均体重3.5kg的兔子作为研究对象，以髂内动脉（IA）注射CDDP（1.7mg/kg）为实验组，以经外周静脉（IV）注射CDDP为对照组。通过IA途径分别给予CDDP 2分钟、20分钟或2小时，或通过IV途径分别给予CDDP 2分钟或20分钟。在CDDP灌注后，测量血清以及子宫和肾脏组织中的铂（Pt）浓度。IA灌注后血清中滤过Pt的浓度显著降低，子宫组织中Pt的浓度显著升高。IA灌注20分钟后，子宫组织中Pt的浓度最高。然而，IA灌注2小时后的子宫Pt浓度与IV灌注后的浓度没有差异。IA灌注后肾脏组织中也保留了大量Pt，这与IV灌注后没有差异。兔模型的这些研究结果表明，IA灌注CDDP 20分钟对子宫癌治疗有效。
