雌二醇、2-羟基雌二醇和4-羟基雌二醇对未成熟大鼠子宫鸟氨酸脱羧酶活性影响的比较。

A comparison of the effects of estradiol and 2- and 4-hydroxyestradiol on uterine ornithine decarboxylase activity in immature rats.

作者信息

Kogo H, Johnson D C, Dey S K, Takeo S

机构信息

Department of Pharmacology, Tokyo College of Pharmacy, Japan.

出版信息

Jpn J Pharmacol. 1993 Jan;61(1):65-7. doi: 10.1254/jjp.61.65.

DOI:10.1254/jjp.61.65

PMID:8437370

Abstract

Effects of estradiol (E2) and catechol-estrogens (CEs: 2-OHE2 and 4-OHE2) on uterine ornithine decarboxylase (ODC) activity have been compared in immature rats. The intensity of their actions by s.c. (1 microgram) and intrauterine right-horn (i.u., 25 ng) injection was in the order of: 4-OHE2 > or = E2 > 2-OHE2. Although i.u. -injection of E2 caused an increase in ODC activity in the left (intact)-horn, which was about 60% that of the right-horn, the effects by CEs were limited only to the right-horn. The results are consistent with the previous view about the order of the potency of 4-OHE2 and 2-OHE2 and also suggest that locally produced CEs may play a role in the physiological functions of the production site.

摘要

在未成熟大鼠中比较了雌二醇（E2）和儿茶酚雌激素（CEs：2-羟基雌二醇和4-羟基雌二醇）对子宫鸟氨酸脱羧酶（ODC）活性的影响。通过皮下注射（1微克）和子宫右角内注射（i.u.，25纳克），它们作用的强度顺序为：4-羟基雌二醇≥E2＞2-羟基雌二醇。尽管子宫内注射E2会使左（完整）角的ODC活性增加，约为右角的60%，但CEs的作用仅限于右角。这些结果与之前关于4-羟基雌二醇和2-羟基雌二醇效力顺序的观点一致，也表明局部产生的CEs可能在产生部位的生理功能中发挥作用。