Sadove R C, Rodgers J B, Fink B F, McRoberts J W
Division of Plastic Surgery, University of Kentucky Chandler Medical Center, Lexington.
Plast Reconstr Surg. 1993 Mar;91(3):511-21. doi: 10.1097/00006534-199303000-00018.
An experiment was performed in Yucatan miniature swine to determine the feasibility and characteristics of musculocutaneous or musculoperitoneal flaps as urinary bladder wall substitutes. In five swine, a single-pedicle skin island flap (rectus abdominis myocutaneous, RAM/C) was sutured into the bladder. In five other swine the flap was a peritoneum island (rectus abdominis myoperitoneal, RAM/P). Three swine were sham-operated controls. The patches were in place for 20 weeks, remaining viable and elastic. Inflammation, maceration, and infection were absent. Skin patch histology was unchanged. The peritoneal patches became resurfaced with uroepithelium. The sham bladder volume (ml/kg body weight) did not differ significantly from RAM/P bladder volume (p = 0.54). RAM/C bladders were slightly smaller than shams (p = 0.11) and significantly smaller than RAM/P bladders (p = 0.03). Substitution of the bladder wall with RAM patch flaps is feasible. This is an important preliminary step toward our goal of nonenteral urinary bladder wall substitution.
在尤卡坦小型猪身上进行了一项实验，以确定肌皮瓣或肌腹膜瓣作为膀胱壁替代物的可行性和特性。在5头猪中，将单蒂皮岛瓣（腹直肌肌皮瓣，RAM/C）缝合到膀胱中。在另外5头猪中，使用的瓣是腹膜岛瓣（腹直肌肌腹膜瓣，RAM/P）。3头猪作为假手术对照。这些补片放置20周，保持存活且有弹性。没有炎症、浸渍和感染。皮肤补片的组织学没有变化。腹膜补片表面重新覆盖了尿路上皮。假手术组膀胱容量（毫升/千克体重）与RAM/P组膀胱容量无显著差异（p = 0.54）。RAM/C组膀胱略小于假手术组（p = 0.11），且显著小于RAM/P组膀胱（p = 0.03）。用RAM补片瓣替代膀胱壁是可行的。这是朝着我们非肠道膀胱壁替代目标迈出的重要初步步骤。
