Spiegel J F, Spear M A, Brown J M
Department of Radiation Oncology, Stanford University School of Medicine, CA 94305-5468.
Radiother Oncol. 1993 Jan;26(1):79-81. doi: 10.1016/0167-8140(93)90031-3.
We have investigated the feasibility of administration of an effective dose of the hypoxic cytotoxin, SR 4233, Monday-Friday daily for 6 weeks. From a thorough hematological, histopathological and clinical chemistry evaluation throughout the course and during a 3-week recovery period, we conclude that daily administration of a radiopotentiating dose of SR 4233 in mice is well tolerated and that bone marrow suppression is likely to be the dose-limiting toxicity.
我们研究了在周一至周五每天给予有效剂量的低氧细胞毒素SR 4233，持续6周的可行性。通过在整个疗程以及3周恢复期内进行全面的血液学、组织病理学和临床化学评估，我们得出结论，在小鼠中每日给予放射增敏剂量的SR 4233耐受性良好，骨髓抑制可能是剂量限制性毒性。
