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Devising murine models to better adapt clinical protocols: sequential low-dose treatment with anti-CD3 and anti-CD4 monoclonal antibodies to prevent fully mismatched allograft rejection.

作者信息

Campos H H, Bach J F, Chatenoud L

机构信息

INSERM Unité 25, Hôpital Necker, Paris, France.

出版信息

Transplant Proc. 1993 Feb;25(1 Pt 1):798-9.

PMID:8438486
Abstract
摘要

相似文献

1
Devising murine models to better adapt clinical protocols: sequential low-dose treatment with anti-CD3 and anti-CD4 monoclonal antibodies to prevent fully mismatched allograft rejection.设计小鼠模型以更好地适配临床方案：采用抗CD3和抗CD4单克隆抗体序贯低剂量治疗以预防完全不匹配的同种异体移植排斥反应。
Transplant Proc. 1993 Feb;25(1 Pt 1):798-9.
2
Evidence that a "four-cell cluster" may prime cytotoxic T-cells during graft rejection.
Transplant Proc. 1993 Feb;25(1 Pt 2):847-9.
3
Inhibition of allograft rejection by anti-T-cell receptor-alpha beta monoclonal antibodies preserving resistance to bacterial infection.抗T细胞受体αβ单克隆抗体抑制同种异体移植排斥反应并保留对细菌感染的抵抗力。
Immunology. 1994 Feb;81(2):198-204.
4
CD4 monoclonal antibodies in the preclinical dog renal allograft model.
Transplant Proc. 1993 Feb;25(1 Pt 1):804-6.
5
A combination of anergic cells' adoptive transfer and rapamycin therapy prolongs cardiac allograft survival in mice.无反应性细胞的过继转移与雷帕霉素治疗相结合可延长小鼠心脏同种异体移植的存活时间。
Scand J Immunol. 2005 Mar;61(3):266-73. doi: 10.1111/j.1365-3083.2005.01555.x.
6
Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed to T cells or their subsets. II. Differential effectiveness of IgG2a and IgG2b isotypes of anti-CD3 and anti-CD4 moAb.通过针对T细胞或其亚群的单克隆抗体预防小鼠致死性移植物抗宿主病。II. 抗CD3和抗CD4单克隆抗体的IgG2a和IgG2b同种型的不同有效性
Bone Marrow Transplant. 1994 Oct;14(4):535-43.
7
The use of an anti-CD3 priming dose to enhance the immunosuppressive potency of monoclonal and polyclonal T-cell antisera.使用抗CD3预充剂量来增强单克隆和多克隆T细胞抗血清的免疫抑制效力。
Transplant Proc. 1991 Feb;23(1 Pt 1):626-9.
8
Interaction between CD4 and CD8 T cells determines graft outcome in monoclonal antibody-treated mice.
Transplant Proc. 1993 Feb;25(1 Pt 1):792-3.
9
Anti-CD4 IgG2a monoclonal antibody treatment prevents the expansion of T cells in the spleen during murine graft-vs-host disease.抗CD4 IgG2a单克隆抗体治疗可预防小鼠移植物抗宿主病期间脾脏中T细胞的扩增。
Transplant Proc. 1995 Feb;27(1):384-6.
10
Low-dose anti-CD3 therapy provides long-term graft survival in a Lewis rat to C57BL/6 xeno-islet transplantation model.
Transplant Proc. 1994 Apr;26(2):771-3.

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1
Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-β dependent regulatory T cells.抗 CD3 抗体通过诱导 IL-10 和 TGF-β 依赖性调节性 T 细胞来改善实验性自身免疫性葡萄膜炎。
Clin Immunol. 2011 Mar;138(3):311-20. doi: 10.1016/j.clim.2010.12.016. Epub 2011 Jan 21.
2
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.抗CD3抗体可诱导非肥胖糖尿病小鼠明显的自身免疫长期缓解。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):123-7. doi: 10.1073/pnas.91.1.123.