Innis S M, Quinlan P, Diersen-Schade D
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Am J Clin Nutr. 1993 Mar;57(3):382-90. doi: 10.1093/ajcn/57.3.382.
Human milk contains a large proportion of palmitic acid (16:0) with > 70% esterified to the center sn-2 position of the milk triglyceride. Infant formulas often use 8:0 + 10:0 [medium-chain triglyceride (MCT)] or 12:0 + 14:0 (coconut oil) as the saturated fat. The effect of formula saturated fatty acid composition; 8:0 + 10:0, 12:0 + 14:0, or 16:0 from palm oil or synthesized triglyceride containing predominantly sn-2 16:0 on plasma lipids and fatty acids was studied in piglets. Although the formulas contained similar 18:1 and 18:2n-6, plasma lipid percentages of 18:1 and 18:2n-6 were higher in piglets fed the formula with MCT or coconut oil rather than the formulas with 16:0, or sow milk. The sn-2 16:0 of the synthesized triglyceride had unique properties. Specifically, piglets fed synthesized triglyceride had significantly higher cholesteryl ester 16:0 identical to that in piglets fed sow milk and higher plasma total and high-density-lipoprotein cholesterol than piglets fed the other formulas.
人乳中含有很大比例的棕榈酸（16:0），其中70%以上酯化到乳甘油三酯的中心sn-2位。婴儿配方奶粉通常使用8:0 + 10:0[中链甘油三酯（MCT）]或12:0 + 14:0（椰子油）作为饱和脂肪。研究了配方奶粉饱和脂肪酸组成（8:0 + 10:0、12:0 + 14:0或来自棕榈油或主要含sn-2 16:0的合成甘油三酯的16:0）对仔猪血浆脂质和脂肪酸的影响。尽管这些配方奶粉含有相似的18:1和18:2n-6，但与喂食含16:0的配方奶粉或母乳的仔猪相比，喂食含MCT或椰子油配方奶粉的仔猪血浆中18:1和18:2n-6的脂质百分比更高。合成甘油三酯的sn-2 16:0具有独特的性质。具体而言，与喂食其他配方奶粉的仔猪相比，喂食合成甘油三酯的仔猪的胆固醇酯16:0显著更高，与喂食母乳的仔猪相同，且血浆总胆固醇和高密度脂蛋白胆固醇更高。
