Polk H C
Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
Am J Surg. 1993 Feb;165(2A Suppl):2S-7S. doi: 10.1016/s0002-9610(05)81200-0.
Infection after injury is characterized by the degree of contamination, the duration of attendant hypotension, and the delay in definitive surgical treatment. Factors further influencing this outcome include the age of the patient and, in most U.S. urban centers, the general health of the patient. Current antibiotic treatment of such patients may soon be assisted by selective and sequential immunostimulants, which are increasingly more specific for defined defects in host defenses after injury. An ever more significant contribution to morbidity and mortality on trauma services is pneumonia, which is often caused by gram-negative aerobes. The design of clinically significant trials with respect to infection in the injury patient will be more difficult and complex.
创伤后感染的特征在于污染程度、伴随的低血压持续时间以及确定性手术治疗的延迟。进一步影响这一结果的因素包括患者的年龄，以及在美国大多数城市中心，患者的总体健康状况。目前对此类患者的抗生素治疗可能很快会得到选择性和序贯性免疫刺激剂的辅助，这些免疫刺激剂对创伤后宿主防御中特定的缺陷越来越具有特异性。肺炎对创伤服务中发病率和死亡率的影响越来越大，肺炎通常由革兰氏阴性需氧菌引起。关于创伤患者感染的具有临床意义的试验设计将更加困难和复杂。
