Rutledge S L, Geraghty M, Mroczek E, Rosenblatt D, Kohout E
Department of Pediatrics, University of Alabama, Birmingham.
Pediatr Nephrol. 1993 Feb;7(1):81-2. doi: 10.1007/BF00861581.
We report two patients with methylmalonic acidemia (MMA) in whom renal biopsy demonstrated interstitial nephritis, bringing the total of such reported cases to four. In addition, hypertension, observed in one of our patients, has not been previously reported as the presentation of renal disease in MMA. The etiology of interstitial nephritis in MMA did not appear to be due to urate nephropathy. To date, 15 patients with MMA have been reported with renal complications, including chronic renal failure, making it imperative that children with MMA have their renal status evaluated.
我们报告了两名甲基丙二酸血症（MMA）患者，其肾活检显示为间质性肾炎，使此类报告病例总数达到4例。此外，我们其中一名患者出现的高血压，此前尚未有作为MMA肾脏疾病表现的相关报道。MMA中间质性肾炎的病因似乎并非尿酸盐肾病所致。迄今为止，已有15例MMA患者被报道出现肾脏并发症，包括慢性肾衰竭，因此对MMA患儿进行肾脏状况评估势在必行。
