Clark C M, Kopala L, James G, Hurwitz T, Li D
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Biol Psychiatry. 1993 Jan 15;33(2):86-92. doi: 10.1016/0006-3223(93)90306-x.
Patterns of regional cerebral glucose metabolism were examined in a group of patients with schizophrenia (n = 17) and normal controls (n = 16) to determine if different metabolic profiles were present. For the patients with schizophrenia, two profiles were found. The first was characterized by a normal "shape" but overall reductions in cerebral metabolism. The second had focal reductions in frontal metabolism. This latter group also had significantly larger frontal horns than the other schizophrenic group. The two groups with schizophrenia did not differ on other attributes or clinical variables. These results are discussed in terms of our understanding of heterogeneity in schizophrenia and etiology.
对一组精神分裂症患者（n = 17）和正常对照组（n = 16）的局部脑葡萄糖代谢模式进行了检查，以确定是否存在不同的代谢特征。对于精神分裂症患者，发现了两种特征。第一种特征是“形状”正常，但脑代谢总体降低。第二种特征是额叶代谢局部降低。后一组患者的额角也明显大于另一组精神分裂症患者。这两组精神分裂症患者在其他属性或临床变量上没有差异。根据我们对精神分裂症异质性和病因学的理解对这些结果进行了讨论。
