McKellar Q A, Jackson F, Coop R L, Baggot J D
Department of Veterinary Pharmacology, University of Glasgow, Veterinary School, Bearsden.
Br Vet J. 1993 Jan-Feb;149(1):101-13. doi: 10.1016/S0007-1935(05)80213-1.
Netobimin and albendazole were administered to 3-month-old lambs with moderate infections of Nematodirus battus and to comparable parasite-naive lambs. Albendazole sulphoxide and albendazole sulphone concentrations were determined in the plasma of all lambs at frequent intervals after treatment. Both anthelmintic preparations were 100% effective in reducing nematode faecal egg output in the lambs. There were no significant differences in the concentrations of the sulphoxide or sulphone metabolites in parasitized compared with non-parasitized lambs given the same parent anthelmintic. The parasite-naive lambs were subsequently weaned and maintained indoors in conditions designed to preclude nematode parasite infection until they were 9 months old. Netobimin and albendazole were administered again and the plasma profiles of the albendazole sulphoxide and albendazole sulphone metabolites determined. There were no significant differences in the plasma distribution of these metabolites with age of the lambs. The area under the plasma concentration time curve, mean resident time and apparent half-life of the albendazole sulphoxide metabolite was determined following administration of each parent drug and the clearance of the metabolite/systemic availability of parent drug was determined as a marker of the amount of drug available for metabolism. There were no significant differences in pharmacokinetic variables between parasitized and non-parasitized animals nor with the age of the animals.
将奈托比明和阿苯达唑分别给予感染中度巴氏细颈线虫的3月龄羔羊以及未感染寄生虫的对照羔羊。治疗后，定期测定所有羔羊血浆中阿苯达唑亚砜和阿苯达唑砜的浓度。两种驱虫制剂在降低羔羊粪便线虫虫卵排出量方面均有100%的效果。给予相同母体驱虫药的情况下，感染寄生虫的羔羊与未感染寄生虫的羔羊相比，其亚砜或砜代谢物的浓度无显著差异。随后，将未感染寄生虫的羔羊断奶，并在设计为防止线虫寄生虫感染的条件下在室内饲养至9月龄。再次给予奈托比明和阿苯达唑，并测定阿苯达唑亚砜和阿苯达唑砜代谢物的血浆浓度曲线。这些代谢物在羔羊血浆中的分布与羔羊年龄无显著差异。每次给予母体药物后，测定阿苯达唑亚砜代谢物的血浆浓度-时间曲线下面积、平均驻留时间和表观半衰期，并将代谢物清除率/母体药物的全身可用性作为可用于代谢的药物量的指标进行测定。感染寄生虫和未感染寄生虫的动物之间以及不同年龄的动物之间，药代动力学变量均无显著差异。
