Lautt W W, Skelton F S
Can J Physiol Pharmacol. 1977 Feb;55(1):7-12. doi: 10.1139/y77-002.
Hepatic blood flow and hepatic uptake of lidocaine were determined in cats during constant intravenous infusion of lidocaine. Lidocaine clearance is directly linked to hepatic blood flow with reductions in flow being reflected in equal reductions in hepatic clearance. Altered blood flow did not result in altered rates of lidocaine extraction. Lidocaine extraction ratio was 28%. Hepatic blood flow and lidocaine metabolism were measured before and 60 min after an intramuscular injection of SKF-525A (50 mg/kg). SKF-525A produced a reduction in hepatic clearance of lidocaine to 60% of control values, entirely as a result of a reduction in hepatic extraction ratios. Hepatic blood flow and vascular conductance were not affected by SKF-525A.
在持续静脉输注利多卡因期间，测定了猫的肝血流量和利多卡因的肝摄取量。利多卡因清除率与肝血流量直接相关，血流量的减少反映在肝清除率的同等程度降低上。血流改变并未导致利多卡因提取率改变。利多卡因提取率为28%。在肌肉注射SKF - 525A（50mg/kg）之前和之后60分钟测量肝血流量和利多卡因代谢情况。SKF - 525A使利多卡因的肝清除率降至对照值的60%，这完全是由于肝提取率降低所致。肝血流量和血管传导性不受SKF - 525A影响。
