Mazan S, Mattéi M G, Roeckel N, Qu L H, Bachellerie J P
Laboratoire de Biologie Moléculaire Eucaryote, Centre National de la Recherche Scientifique (CNRS), UPR 9006, Université Paul-Sabatier, Toulouse, France.
Cytogenet Cell Genet. 1993;62(4):203-6. doi: 10.1159/000133476.
U3 small nucleolar RNA, which participates in eukaryotic rRNA processing, is encoded by a small multigene family in mammals. In humans, the four to six gene copies code for an identical U3 RNA molecule; rodents, however, have two variant forms of these genes, U3A and U3B. We show that all U3 genes in humans map to a single chromosomal locus, 17p12-->-p11, which corresponds exactly to the region of mouse Chromosome 11 where the four U3B genes are clustered. By contrast, in mouse the unique U3A gene copy is not linked to the U3B gene cluster but maps to another chromosome (the B2-B4 region of Chromosome 10).
U3小核仁RNA参与真核生物核糖体RNA（rRNA）的加工，由哺乳动物中的一个小多基因家族编码。在人类中，四到六个基因拷贝编码相同的U3 RNA分子；然而，啮齿动物有这些基因的两种变体形式，U3A和U3B。我们发现人类所有的U3基因都定位于一个单一的染色体位点，即17p12→p11，这正好对应于小鼠11号染色体上四个U3B基因聚集的区域。相比之下，在小鼠中，独特的U3A基因拷贝不与U3B基因簇相连，而是定位于另一条染色体（10号染色体的B2 - B4区域）。
