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溴高异鹅膏蕈氨酸的非去极化D型增强了由L型或喹啉酸盐引起的去极化。

The non-depolarizing D-form of bromohomoibotenic acid enhances depolarizations evoked by the L-form or quisqualate.

作者信息

Madsen U, Ebert B, Hansen J J, Krogsgaard-Larsen P

机构信息

Department of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen.

出版信息

Eur J Pharmacol. 1993 Jan 19;230(3):383-6. doi: 10.1016/0014-2999(93)90579-7.

DOI:10.1016/0014-2999(93)90579-7
PMID:8440315
Abstract

The D-enantiomer of bromohomoibotenic acid (Br-HIBO) was inactive in electrophysiological experiments when administered alone, but enhanced depolarizations evoked by L-Br-HIBO or quisqualate when co-administered with these agonists. In addition, quisqualate induced a long-lasting (> 120 min) sensitization of cortical wedge neurons to D-Br-HIBO. This latter effect of D-Br-HIBO was similar to, but significantly more potent and selective, than the earlier observed quisqualate-induced sensitization of cortical neurones to depolarization by (S)-2-amino-4-phosphonobutyric acid (L-AP4).

摘要

溴高鹅膏蕈氨酸（Br-HIBO）的D-对映体单独给药时在电生理实验中无活性，但与这些激动剂共同给药时可增强L-Br-HIBO或喹啉酸诱发的去极化作用。此外，喹啉酸可诱导皮质楔形神经元对D-Br-HIBO产生持久（>120分钟）的敏感性。D-Br-HIBO的后一种作用与早期观察到的喹啉酸诱导的皮质神经元对（S）-2-氨基-4-膦酰丁酸（L-AP4）去极化的敏感性相似，但效力明显更强且更具选择性。

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