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雄性胎儿的雄激素介导效应在妊娠后期对母鼠行为的影响。

Androgen mediated effects of male fetuses on the behavior of dams late in pregnancy.

作者信息

Clark M M, Crews D, Galef B G

机构信息

Department of Psychology, McMaster University, Hamilton, Ontario, Canada.

出版信息

Dev Psychobiol. 1993 Jan;26(1):25-35. doi: 10.1002/dev.420260103.

DOI:10.1002/dev.420260103
PMID:8440402
Abstract

Two correlational studies were undertaken to explore the relationship between the sex ratio of the pups that a female Mongolian gerbil gestated and her behavior, morphology, and hormone levels late in pregnancy. In the first study, we found that the change in sex ratio between the first and second litters that a female gerbil delivered and the change in her frequency of scent marking late in her first and second pregnancies were significantly correlated. In the second study, we found significant positive correlations between both the percentage and the number of males in the litter a female delivered and (1) her plasma testosterone levels, (2) the size of her ventral gland, and (3) her frequency of scent marking, all measured late in pregnancy. Our data were entirely consistent with the hypothesis that fetal males excrete biologically significant quantities of testosterone into their dam's bloodstream and that this testosterone masculinizes both the behavior and morphology of dams late in pregnancy.

摘要

进行了两项相关性研究,以探讨雌性蒙古沙鼠所孕育幼崽的性别比例与其妊娠后期行为、形态及激素水平之间的关系。在第一项研究中,我们发现雌性沙鼠所产第一窝和第二窝幼崽的性别比例变化,与它在第一次和第二次妊娠后期气味标记频率的变化显著相关。在第二项研究中,我们发现雌性沙鼠所产一窝幼崽中雄性的百分比和数量,与(1)其血浆睾酮水平、(2)腹腺大小、(3)气味标记频率均呈显著正相关,所有这些均在妊娠后期测量。我们的数据完全符合以下假设:雄性胎儿会向其母鼠的血液中分泌具有生物学意义数量的睾酮,并且这种睾酮会使母鼠在妊娠后期的行为和形态男性化。

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Androgen mediated effects of male fetuses on the behavior of dams late in pregnancy.雄性胎儿的雄激素介导效应在妊娠后期对母鼠行为的影响。
Dev Psychobiol. 1993 Jan;26(1):25-35. doi: 10.1002/dev.420260103.
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