多发性肌炎/皮肌炎患者中的HLA-DP阳性T细胞。
HLA-DP positive T cells in patients with polymyositis/dermatomyositis.
作者信息
Kanai Y, Tokano Y, Tsuda H, Hashimoto H, Okumura K, Hirose S
机构信息
Department of Internal Medicine and Immunology, Juntendo University, School of Medicine, Tokyo, Japan.
出版信息
J Rheumatol. 1993 Jan;20(1):77-9.
The examination of HLA-DP+ T cells in 21 patients with polymyositis/dermatomyositis revealed marked increases [28.5% (SD 16.6%)], compared with the HLA-DQ+ and DR+ T cells. The HLA-DP molecule was expressed on both CD4+ and CD8+ T cells. The majority of HLA-DP+ CD8+ cells were cytotoxic T cells. There was no significant correlation between the proportion of HLA-DP+ T cells and the level of myogenic enzyme, although a decrease in HLA-DP+ T cells after therapy was accompanied by a decrease in myogenic enzymes. However, the proportion of HLA-DP+ CD8+ cells was significantly higher in those patients with active pneumonitis.
对21例多发性肌炎/皮肌炎患者的HLA-DP⁺ T细胞进行检测发现，与HLA-DQ⁺和DR⁺ T细胞相比，其数量显著增加[28.5%（标准差16.6%）]。HLA-DP分子在CD4⁺和CD8⁺ T细胞上均有表达。大多数HLA-DP⁺ CD8⁺细胞是细胞毒性T细胞。HLA-DP⁺ T细胞比例与肌源酶水平之间无显著相关性，尽管治疗后HLA-DP⁺ T细胞减少伴随着肌源酶降低。然而，活动性肺炎患者中HLA-DP⁺ CD8⁺细胞的比例显著更高。
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