前列腺癌：外照射治疗结果
Prostate cancer: results of external irradiation.
作者信息
Reddy E K, Krishnan L, Giri S, Evans R G, Mebust W K, Weigel J W
机构信息
Department of Radiation Oncology, University of Kansas Medical Center, Kansas City.
出版信息
J Natl Med Assoc. 1993 Feb;85(2):109-12.
From 1975 to 1982, 205 patients with local prostate cancer were treated at the radiation oncology department, the University of Kansas Medical Center, Kansas City, Kansas. Patients' median age was 73 years. All of the patients were staged according to American Urologic staging criteria. Twenty-eight patients had stage A2 cancer, 91 patients had stage B cancer, and 86 patients had stage C cancer. All patients were treated using megavoltage radiation (dosage range: 6000 cGy to 7100 cGy). The follow-up period ranged from a minimum of 8 years to a maximum of 15 years (median: 9.4 years). The clinical local control was 96% for stage A2, 94% for stage B, and 90% for stage C disease. The overall and disease-free survival rates were 71% and 60%, respectively. Fourteen patients developed moderate complications with one patient (0.5%) requiring surgical intervention. The local control and survival rates reported in this study are comparable with surgical results, suggesting that external beam irradiation in prostate cancer is safe and effective.
1975年至1982年期间，堪萨斯大学医学中心放射肿瘤学部门对205例局部前列腺癌患者进行了治疗，这些患者来自堪萨斯州堪萨斯城。患者的中位年龄为73岁。所有患者均根据美国泌尿外科分期标准进行分期。28例患者为A2期癌症，91例患者为B期癌症，86例患者为C期癌症。所有患者均接受兆伏级放疗（剂量范围：6000厘戈瑞至7100厘戈瑞）。随访期最短为8年，最长为15年（中位值：9.4年）。A2期疾病的临床局部控制率为96%，B期为94%，C期为90%。总体生存率和无病生存率分别为71%和60%。14例患者出现中度并发症，其中1例患者（0.5%）需要手术干预。本研究报告的局部控制率和生存率与手术结果相当，表明前列腺癌的外照射是安全有效的。
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