Sperling N M, Paparella M M, Yoon T H, Zelterman D
Department of Otolaryngology-Head and Neck Surgery, State University of New York-Health Science Center, Brooklyn 11201.
Laryngoscope. 1993 Mar;103(3):277-85. doi: 10.1288/00005537-199303000-00007.
One of the unanswered questions in Meniere's disease research is the pathophysiology by which the classic symptoms are produced. A histopathological study was undertaken to identify the pathological features of symptomatic endolymphatic hydrops and their relationship to these symptoms. Two groups of temporal bones were examined, compared, and described. The first group was from patients with symptoms of Meniere's disease (n = 29). Temporal bones in the second group were chosen for the presence of endolymphatic hydrops and the absence of otologic symptoms (n = 13). Significant differences were noted in the severity of hydrops, the frequency of membrane ruptures, the endolymphatic duct, and coexistent pathologic conditions. Ruptures were seen in 38% of temporal bones from symptomatic patients and in only 8% of temporal bones from patients with asymptomatic endolymphatic hydrops. Based on this study and a review of the literature, the authors believe that the symptoms and findings of Meniere's disease are explained best on the basis of both chemical and physical mechanisms being operational intermittently and together.
梅尼埃病研究中尚未解决的问题之一是产生典型症状的病理生理学机制。开展了一项组织病理学研究，以确定有症状的内淋巴积水的病理特征及其与这些症状的关系。对两组颞骨进行了检查、比较和描述。第一组来自有梅尼埃病症状的患者（n = 29）。第二组颞骨是因存在内淋巴积水且无耳科症状而选取的（n = 13）。在积水的严重程度、膜破裂的频率、内淋巴管以及并存的病理状况方面发现了显著差异。有症状患者的颞骨中38%出现了破裂，而无症状内淋巴积水患者的颞骨中只有8%出现破裂。基于这项研究以及对文献的回顾，作者认为梅尼埃病的症状和表现最好基于化学和物理机制间歇性且共同起作用来解释。
