Kortelainen S, Larmas M
Institute of Dentistry, University of Oulu, Finland.
Scand J Dent Res. 1993 Feb;101(1):16-20. doi: 10.1111/j.1600-0722.1993.tb01639.x.
The effect of fluoride in drinking water on the progression of dentinal caries and dentin apposition was studied in Wistar rats. The initiation of enamel caries lesions was first induced for 2 wk with S. sobrinus and a 43% sucrose diet after weaning. Thereafter the animals were fed on either a cariogenic or a non-cariogenic diet and distilled water supplemented with 0, 1, 7 or 19 ppm fluoride. The areas of dentinal caries and dentin apposition were quantified after tetracycline staining. Fluoride reduced dentinal caries progression after the initiation of lesions in the presence of a cariogenic diet at a concentration of 19 ppm F, and without sucrose at 1 ppm F. The effect of fluoride in reducing dentin apposition with a cariogenic diet was dose-dependent, whereas fluoride in non-cariogenic groups had practically no effect on dentin formation. These results suggest that fluoride together with a high concentration of sucrose in the diet might have an odontoblast-mediated effect on the regulation of the progression of dentinal caries.
在Wistar大鼠中研究了饮用水中的氟对牙本质龋进展和牙本质沉积的影响。断奶后，先用远缘链球菌和43%蔗糖饮食诱导牙釉质龋损起始2周。此后，动物分别喂食致龋或非致龋饮食，并饮用补充有0、1、7或19 ppm氟的蒸馏水。四环素染色后对牙本质龋和牙本质沉积区域进行定量分析。在致龋饮食存在的情况下，浓度为19 ppm F时，氟可减少龋损起始后牙本质龋的进展；在无糖情况下，1 ppm F的氟也有此作用。致龋饮食条件下，氟减少牙本质沉积的作用呈剂量依赖性，而非致龋组中的氟对牙本质形成几乎没有影响。这些结果表明，饮食中的氟与高浓度蔗糖一起可能对成牙本质细胞介导的牙本质龋进展调节产生影响。
