Nederfors T, Henricsson V, Dahlöf C, Axéll T
Department of Clinical Pharmacology, Sahlgrenska Hospital, Faculty of Odontology, University of Gothenburg, Sweden.
Scand J Dent Res. 1993 Feb;101(1):44-8. doi: 10.1111/j.1600-0722.1993.tb01645.x.
Assessment of oral mucosal friction and subjective perception of dry mouth was performed during treatment with thiazide diuretic bendroflumethiazide (2.5 mg o.d.) or placebo in a randomized, double-blind, cross-over study (2 x 2 wk) in 34 healthy volunteers. Treatment with bendroflumethiazide was associated with a 10% reduction in the stimulated whole saliva secretion rate and a 15% reduction in the salivary sodium concentration, as compared with placebo. Oral mucosal friction was concomitantly measured on the buccal mucosa and on the mucosa of the lower lip by means of a newly developed sliding friction device. In addition, a questionnaire was used to evaluate how the treatment was subjectively perceived with regard to symptoms of dry mouth. Mucosal friction of the lower lip increased significantly during treatment with bendroflumethiazide, as compared with placebo. When the test subjects, regardless of pharmacologic treatment, were divided into groups according to subjective perception of dry mouth, the dry mouth group showed significantly lower resting and stimulated flow rate and higher mucosal friction in comparison to the nondry group. When, in addition, pharmacologic treatment was also considered, the differences between the dry and the nondry group were restricted to resting whole saliva flow rate and mucosal friction during bendroflumethiazide treatment. It is concluded that resting whole saliva flow rate is the best predictive factor for evaluating subjectively perceived dry mouth. However, the sensitivity of the developed sliding friction device is capable of detecting minor changes in salivary secretion rate. In addition, measurements of oral mucosal friction may serve as an easily available method to complement sialometry when evaluating, for example, drug-induced dryness of the mouth.
在一项针对34名健康志愿者的随机、双盲、交叉研究（2×2周）中，使用噻嗪类利尿剂苄氟噻嗪（每日2.5毫克）或安慰剂进行治疗期间，对口腔黏膜摩擦力和口干的主观感受进行了评估。与安慰剂相比，苄氟噻嗪治疗使刺激后的全唾液分泌率降低了10%，唾液钠浓度降低了15%。通过一种新开发的滑动摩擦装置，同时测量颊黏膜和下唇黏膜的口腔黏膜摩擦力。此外，还使用了一份问卷来评估受试者对治疗引起的口干症状的主观感受。与安慰剂相比，苄氟噻嗪治疗期间下唇的黏膜摩擦力显著增加。当根据口干的主观感受将受试者（无论药物治疗情况如何）分组时，与非口干组相比，口干组的静息和刺激流速显著降低，黏膜摩擦力更高。此外，当考虑药物治疗时，口干组和非口干组之间的差异仅限于苄氟噻嗪治疗期间的静息全唾液流速和黏膜摩擦力。研究得出结论，静息全唾液流速是评估主观感受到的口干的最佳预测因素。然而，所开发的滑动摩擦装置的灵敏度能够检测到唾液分泌率的微小变化。此外，在评估例如药物引起的口干时，口腔黏膜摩擦力的测量可作为一种易于获得的方法来补充唾液测量法。
