Bacon G E, Spencer M L, Kelch R P
Clin Endocrinol (Oxf). 1977 Feb;6(2):113-26. doi: 10.1111/j.1365-2265.1977.tb02002.x.
The temporal relationship between administration of cortisol and serum 17alpha-hydroxyprogesterone was investigated in five patients aged 9-19 years with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. There was marked variability in the 17alpha-hydroxyprogesterone response (determined hourly for 24 h) of individual patients to administration of cortisol. Mean concentration was less than 0.030 micronmol/l in one patient but 0.519 micronmol/l in another. Levels were higher in all patients while off treatment, and were greatest in those with salt-losing adrenal hyperplasia. Growth hormone secretion was not suppressed by treatment with cortisol. Withdrawal of cortisol for 3 days resulted in a significant decrease in the mean serum FSH/LH ratio and a rise in serum testosterone in all subjects. Episodic release of gonadotrophins persisted in the adolescent patients.
对5名年龄在9至19岁、因21-羟化酶缺乏导致先天性肾上腺皮质增生的患者，研究了皮质醇给药与血清17α-羟孕酮之间的时间关系。个体患者对皮质醇给药的17α-羟孕酮反应（24小时每小时测定）存在显著差异。一名患者的平均浓度低于0.030微摩尔/升，而另一名患者为0.519微摩尔/升。所有患者在未治疗时水平较高，在失盐型肾上腺皮质增生患者中最高。生长激素分泌未被皮质醇治疗所抑制。所有受试者停用皮质醇3天导致平均血清促卵泡激素/促黄体生成素比值显著下降，血清睾酮升高。青春期患者促性腺激素的间歇性释放持续存在。
