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[热带疟疾中乙胺嘧啶和磺胺多辛/乙胺嘧啶过量]

[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].

作者信息

Burgmann H, Winkler S, Uhl F, Feucht M, Hellgren U, Bergqvist Y, Feistauer S, Breyer S, Graninger W

机构信息

Abteilung für Infektionen und Chemotherapie, Innere Medizin I, Wien.

出版信息

Wien Klin Wochenschr. 1993;105(2):61-3.

PMID:8442357
Abstract

A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.

摘要

一名39岁的恶性疟原虫疟疾患者,除了接受3250毫克氯喹和175/3500毫克磺胺多辛/乙胺嘧啶治疗外,还在3天内接受了3500毫克甲氟喹治疗。他出现了严重的神经精神症状,不得不住院治疗。使用地西泮、氟哌啶醇和硫利达嗪治疗4天后,严重症状得到缓解。治疗8个月后,患者仍有轻微的神经精神症状。

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