晚期脑萎缩和维生素缺乏对非痴呆受试者认知功能的影响。

Effect of advanced brain atrophy and vitamin deficiency on cognitive functions in non-demented subjects.

作者信息

Pirttilä T, Salo J, Laippala P, Frey H

机构信息

Department of Neurology, Tampere University Hospital, University of Tampere, Finland.

出版信息

Acta Neurol Scand. 1993 Feb;87(2):161-6. doi: 10.1111/j.1600-0404.1993.tb04094.x.

DOI:10.1111/j.1600-0404.1993.tb04094.x

PMID:8442398

Abstract

The relationship between the cognitive functions, structural changes of the brain and vitamin levels was evaluated in 36 non-demented subjects with advanced brain atrophy, and 57 age- and sex-matched healthy controls. In the control subjects ageing was associated with mild decline of cognitive skills, but the cognitive changes were not linked to the structural changes of the brain. In contrast, advanced brain atrophy and vitamin deficiency was related to the decline of complex cognitive functions in the atrophy group. Our results indicate that there are limits of normal age-related changes of the brain structure, and advanced brain atrophy on CT scans increase the probability of mild deficits of the cognitive skills.

摘要

在36名患有晚期脑萎缩的非痴呆受试者以及57名年龄和性别匹配的健康对照者中，对认知功能、脑结构变化与维生素水平之间的关系进行了评估。在对照受试者中，衰老与认知技能的轻度下降有关，但认知变化与脑结构变化并无关联。相比之下，晚期脑萎缩和维生素缺乏与萎缩组复杂认知功能的下降有关。我们的结果表明，脑结构的正常年龄相关变化存在限度，CT扫描显示的晚期脑萎缩会增加认知技能出现轻度缺陷的可能性。