多发性硬化症及其他神经系统疾病中可溶性白细胞介素-2受体的血清和脑脊液水平：重新评估

Serum and CSF levels of soluble interleukin-2 receptors in MS and other neurological diseases: a reappraisal.

作者信息

Chalon M P, Sindic C J, Laterre E C

机构信息

Laboratory of Neurochemistry, Catholic University of Louvain, Brussels, Belgium.

出版信息

Acta Neurol Scand. 1993 Feb;87(2):77-82. doi: 10.1111/j.1600-0404.1993.tb04081.x.

DOI:10.1111/j.1600-0404.1993.tb04081.x

PMID:8442399

Abstract

Soluble interleukin-2 receptors (sIL-2-R) were determined longitudinally in sera from 59 patients with multiple sclerosis (MS), from 20 patients with Guillain-Barré syndrome (GBS) and from patients with other non-inflammatory disorders of the nervous system, as well as in 147 CSF samples collected for diagnostic purposes. Significantly increased serum levels of sIL2-R were observed early in the course of GBS and in progressive (relapsing or chronic) MS, but not in patients with clinically stable MS or with an acute relapse followed by complete remission. CSF levels were high in infections of the central nervous system and in meningeal carcinomatosis, as a result of an intrathecal production, but were normal in GBS and in most (94%) MS patients.

摘要

对59例多发性硬化症（MS）患者、20例吉兰 - 巴雷综合征（GBS）患者以及患有其他非炎性神经系统疾病的患者的血清进行纵向可溶性白细胞介素 - 2受体（sIL - 2 - R）测定，并对147份用于诊断目的而采集的脑脊液样本进行测定。在GBS病程早期以及进展型（复发型或慢性型）MS患者中观察到血清sIL2 - R水平显著升高，但临床稳定的MS患者或急性复发后完全缓解的患者中未观察到升高。由于鞘内产生，中枢神经系统感染和脑膜癌病患者的脑脊液水平较高，但GBS患者和大多数（94%）MS患者的脑脊液水平正常。