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抗生素相关性腹泻能否预防?

[Can antibiotic-associated diarrhea be prevented?].

作者信息

Loizeau E

机构信息

Hôpital cantonal universitaire de Genève, Suisse.

出版信息

Ann Gastroenterol Hepatol (Paris). 1993 Jan-Feb;29(1):15-8.

PMID:8442650
Abstract

Post-antibiotic diarrhea is common but rarely serious. The chief cause is changes in the normal intestinal flora. Decrease in the number of bacteria leads to maldigestion of carbohydrates, resulting in osmotic diarrhea. Disappearance of the flora encourages the emergence of resistant strains, e.g. Clostridium difficile. General measures concern the prescription of antibiotics and the use of probiotics. The latter restore and replace the normal flora and prevent more than half of all cases of diarrhea, in particular serious forms and pseudo-membranous colitis. Antibiotics are not accompanied by any complication in 80% of instances. Probiotics should be used in high risk patients: elderly, seriously ill or hospitalised for long periods.

摘要

抗生素相关性腹泻很常见,但很少严重。主要原因是正常肠道菌群的变化。细菌数量减少导致碳水化合物消化不良,从而引起渗透性腹泻。菌群的消失促使耐药菌株出现,例如艰难梭菌。一般措施涉及抗生素的处方和益生菌的使用。后者可恢复并替代正常菌群,预防超过一半的腹泻病例,尤其是严重形式和伪膜性结肠炎。80%的情况下抗生素不会伴有任何并发症。益生菌应用于高危患者:老年人、重症患者或长期住院患者。

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