Johnson H, Belluco C, Masood S, Abou-Azama A M, Kahn L, Wise L
Department of Surgery, Long Island Jewish Medical Center, Albert Einstein College of Medicine, NY.
Arch Surg. 1993 Mar;128(3):314-7. doi: 10.1001/archsurg.1993.01420150070013.
Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31% vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival.
研究胃贲门部及胃体/胃窦部肿瘤，以确定倍体和S期细胞分数对患者生存的影响。42%的肿瘤位于贲门部，58%位于胃体/胃窦部。贲门部肿瘤发生淋巴结转移的频率高于胃体/胃窦部肿瘤（86%对65%）。与胃体/胃窦部肿瘤患者相比，贲门部肿瘤患者非整倍体出现的频率更高（39%对20%）。非整倍体患者发生淋巴结转移比二倍体患者更常见（31%对7%）。非整倍体肿瘤和二倍体肿瘤之间的S期细胞分数没有差异。二倍体癌症患者5年生存率高于非整倍体肿瘤患者（90%对10%）。我们得出结论，胃贲门部或胃体/胃窦部肿瘤的原发性细胞差异决定患者的生存。
