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癌症放射免疫偶联物的成熟

The coming of age of cancer radioimmunoconjugates.

作者信息

Goldenberg D M, Schlom J

机构信息

Garden State Cancer Center, Center for Molecular Medicine and Immunology, Newark, NJ 07103.

出版信息

Immunol Today. 1993 Jan;14(1):5-7. doi: 10.1016/0167-5699(93)90315-C.

Abstract

Great progress in imaging and therapy with radioimmunoconjugates was discussed at the fourth conference on radioimmunodetection and radioimmunotherapy of cancer. Monoclonal antibody-based cancer imaging agents are awaiting marketing approval and newer, potentially improved forms are in development. Tumor responses to radioimmunoconjugates are also being reported in increasing numbers, this is especially so with radiosensitive tumors and in regional or direct applications.

摘要

在第四届癌症放射免疫检测与放射免疫治疗会议上,讨论了放射免疫缀合物在成像和治疗方面取得的重大进展。基于单克隆抗体的癌症成像剂正在等待市场批准,并且更新的、可能有所改进的形式正在研发中。关于肿瘤对放射免疫缀合物的反应的报道也越来越多,在放射敏感肿瘤以及局部或直接应用中尤其如此。

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