Fisher E R, Costantino J, Fisher B, Redmond C
National Surgical Adjuvant Breast and Bowel Project Headquarters, Pittsburgh, Pennsylvania.
Cancer. 1993 Mar 15;71(6 Suppl):2141-50. doi: 10.1002/1097-0142(19930315)71:6+<2141::aid-cncr2820711603>3.0.co;2-f.
Twenty-one pathologic and five clinical features of Stage I and II invasive breast cancers from 620 patients enrolled in National Surgical Adjuvant Breast Project Protocol B-04 were analyzed to determine their predictive value for 15-year survival. Ten pathologic features had a statistically significant univariate prognostic relationship with long-term survival. These were analyzed further using a Cox regression model that found only the number of nodal metastases (0, 1-3, 4-9, or 10+), tumor size (< or = 2.0 cm versus 2.1-4 and 4.1 + cm), and the presence or absence of nipple involvement to be significant independent prognostic discriminants. Combinations of these three characteristics modestly increased their individual prognostic value. Differences in the findings in this study from those observed in the same patient population at 5 and 10 postoperative years and their relationship to other markers detected by ancillary pathologic techniques briefly are discussed.
对参加国家乳腺癌辅助手术项目协议B - 04的620例I期和II期浸润性乳腺癌患者的21项病理特征和5项临床特征进行了分析，以确定它们对15年生存率的预测价值。10项病理特征与长期生存具有统计学上显著的单因素预后关系。使用Cox回归模型对这些特征进行了进一步分析，结果发现只有淋巴结转移数量（0、1 - 3、4 - 9或10个及以上）、肿瘤大小（≤2.0 cm与2.1 - 4 cm和4.1 cm及以上）以及乳头是否受累是显著的独立预后判别因素。这三个特征的组合适度提高了它们各自的预后价值。简要讨论了本研究结果与术后5年和10年在同一患者群体中观察到的结果的差异，以及它们与辅助病理技术检测到的其他标志物的关系。
