García-Peréz A, Narbona-García J, Sierrasesúmaga L, Aguirre-Ventalló M, Calvo-Manuel F
Department of Pediatrics, University Hospital and Medical School, University of Navarra, Pamplona, Spain.
Dev Med Child Neurol. 1993 Feb;35(2):139-48. doi: 10.1111/j.1469-8749.1993.tb11615.x.
With the aim of determining the neuropsychological disturbances associated with cranial radiotherapy in the child, a cross-sectional study was carried out on 25 survivors of medial-edge intracranial tumours. Children irradiated for intracranial tumours experienced deterioration mainly in visual attention and memory, but also in verbal fluency, full-scale IQ, and performance IQ and all its subtests, compared with control groups. This deterioration progressed with time, finally involving at least abstract thought and verbal skills. The pattern of damage by irradiation varied according to the degree of brain maturity, therefore the younger the child at irradiation, the greater the decline in IQ and visual-constructive abilities, and the earlier the deterioration of visual memory and verbal skills.
为了确定与儿童颅脑放疗相关的神经心理障碍，对25例内侧边缘颅内肿瘤幸存者进行了一项横断面研究。与对照组相比，接受颅内肿瘤放疗的儿童主要在视觉注意力和记忆力方面出现衰退，在语言流畅性、全量表智商、操作智商及其所有子测验方面也出现衰退。这种衰退随时间推移而进展，最终至少涉及抽象思维和语言技能。放疗造成的损伤模式因大脑成熟程度而异，因此放疗时儿童年龄越小，智商和视觉构建能力下降越明显，视觉记忆和语言技能衰退越早。
