酚妥拉明、酚苄明和地昔帕明对可乐定引起的犬心脏加速阻滞的影响。

Effects of phentolamine, phenoxybenzamine and desipramine on clonidine-induced blockade of cardiac acceleration in the dog.

作者信息

Scriabine A, Stavorski J M

出版信息

Eur J Pharmacol. 1977 Mar 7;42(1):63-9. doi: 10.1016/0014-2999(77)90191-1.

Abstract

Clonidine reduced cardiac acceleration induced by low frequency electrical stimulation of cardiac sympathetic nerve fibers in anesthetized and vagotomized dogs. This effect of clonidine was abolished by short periods of high frequency electrical stimulation. The inhibitory effect of clonidine was observed with 10- as well as with 90-sec periods of electrical stimulation of sympathetic nerve fibers; it was antagonized by phentolamine, phenoxybenzamine and desipramine. This suggests the presence of alpha-adrenoceptors at the peripheral sympathetic nerve ending in the dog.

摘要

可乐定可降低麻醉且切断迷走神经的犬心脏交感神经纤维低频电刺激所诱发的心脏加速。可乐定的这一效应可被短时间高频电刺激消除。在对交感神经纤维进行10秒和90秒电刺激时均观察到可乐定的抑制作用；酚妥拉明、酚苄明和地昔帕明可拮抗该作用。这提示犬外周交感神经末梢存在α-肾上腺素能受体。