Edwards M S, Rench M A, Hall M A, Baker C J
Department of Pediatrics, Baylor College of Medicine, Houston, Tex. 77030.
J Perinatol. 1993 Jan-Feb;13(1):8-13.
Physical features do not reliably distinguish premature infants with bacterial infections from those with noninfectious conditions. We evaluated the association of depressed plasma fibronectin with sepsis among hospitalized very low birth weight infants (< 1500 gm). Reference values were determined by sequential plasma sampling from 60 healthy very low birth weight infants. Among 17 very low birth weight infants with proved late-onset sepsis (mean age, 20 days; range, 10 to 42 days), 9 had plasma fibronectin levels more than 1 SD below the age- and birth weight-associated mean. Overall, the sensitivity and specificity of the finding of depressed fibronectin levels were 53% and 94%, respectively. These data suggest that depression of plasma fibronectin occurs commonly in association with late-onset sepsis among hospitalized premature infants.
身体特征无法可靠地区分患有细菌感染的早产儿和患有非感染性疾病的早产儿。我们评估了住院的极低出生体重儿（<1500克）中血浆纤维连接蛋白降低与败血症之间的关联。通过对60名健康的极低出生体重儿进行连续血浆采样来确定参考值。在17名已证实患有晚发性败血症的极低出生体重儿中（平均年龄20天；范围10至42天），9名婴儿的血浆纤维连接蛋白水平比与年龄和出生体重相关的平均值低1个标准差以上。总体而言，纤维连接蛋白水平降低这一发现的敏感性和特异性分别为53%和94%。这些数据表明，住院早产儿中血浆纤维连接蛋白降低通常与晚发性败血症有关。
